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The Resource The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, (electronic resource)
The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, (electronic resource)
Resource Information
The item The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Calgary Public Library.This item is available to borrow from all library branches.
Resource Information
The item The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Calgary Public Library.
This item is available to borrow from all library branches.
- Summary
- This work focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this astounding publication
- Language
- eng
- Extent
- 1 online resource (xiii, 303 p., [8] p. of plates)
- Note
- "This book draws extensively from interviews [the author] conducted with those who lived this story. Chronic myeloid leukemia (CML), the blood cancer that is this book's focus, is alternately referred to as chronic myelogenous leukemia."--Author's note
- Contents
-
- Down to the bone : February 2012
- The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes"
- Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man"
- Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory
- Aftermath. A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer
- Survival time
- Isbn
- 9781615191659
- Label
- The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level
- Title
- The Philadelphia chromosome
- Title remainder
- a mutant gene and the quest to cure cancer at the genetic level
- Statement of responsibility
- Jessica Wapner ; foreword by Robert A. Weinberg
- Subject
-
- Cancer -- Research
- Chronic myeloid leukemia -- Genetic aspects
- Chronic myeloid leukemia -- History
- Electronic books
- Fusion Proteins, bcr-abl -- history -- United States
- Genetic Therapy -- history -- United States
- Genetics
- HEALTH & FITNESS / Diseases / Cancer
- History
- Hungerford, David S, 1938-
- Imatinib
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- history -- United States
- MEDICAL / Oncology
- Mutation (Biology)
- Philadelphia Chromosome -- United States
- SCIENCE / Life Sciences / Genetics & Genomics
- Cancer -- Genetic aspects
- Language
- eng
- Summary
- This work focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this astounding publication
- Cataloging source
- N$T
- http://library.link/vocab/creatorName
- Wapner, Jessica
- Dewey number
- 616.99/419042
- Illustrations
-
- illustrations
- plates
- Index
- index present
- LC call number
- RC643
- LC item number
- .W36 2013eb
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- NLM call number
- QZ 11 AA1
- http://library.link/vocab/relatedWorkOrContributorDate
- 1942-
- http://library.link/vocab/relatedWorkOrContributorName
- Weinberg, Robert A.
- http://library.link/vocab/subjectName
-
- Hungerford, David S
- Chronic myeloid leukemia
- Chronic myeloid leukemia
- Cancer
- Cancer
- Mutation (Biology)
- Imatinib
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Philadelphia Chromosome
- Fusion Proteins, bcr-abl
- Genetic Therapy
- HEALTH & FITNESS / Diseases / Cancer
- MEDICAL / Oncology
- SCIENCE / Life Sciences / Genetics & Genomics
- History
- Genetics
- Label
- The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, (electronic resource)
- Note
- "This book draws extensively from interviews [the author] conducted with those who lived this story. Chronic myeloid leukemia (CML), the blood cancer that is this book's focus, is alternately referred to as chronic myelogenous leukemia."--Author's note
- Antecedent source
- unknown
- Bibliography note
- Includes bibliographical references (p. 283-290) and index
- Color
- multicolored
- Contents
- Down to the bone : February 2012 -- The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes" -- Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man" -- Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory -- Aftermath. A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer -- Survival time
- Control code
- ocn843881932
- Dimensions
- unknown
- Extent
- 1 online resource (xiii, 303 p., [8] p. of plates)
- File format
- unknown
- Form of item
- online
- Isbn
- 9781615191659
- Isbn Type
- (electronic bk.)
- Level of compression
- unknown
- Other physical details
- ill. (some col.).
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
- (OCoLC)843881932
- Label
- The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, (electronic resource)
- Note
- "This book draws extensively from interviews [the author] conducted with those who lived this story. Chronic myeloid leukemia (CML), the blood cancer that is this book's focus, is alternately referred to as chronic myelogenous leukemia."--Author's note
- Antecedent source
- unknown
- Bibliography note
- Includes bibliographical references (p. 283-290) and index
- Color
- multicolored
- Contents
- Down to the bone : February 2012 -- The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes" -- Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man" -- Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory -- Aftermath. A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer -- Survival time
- Control code
- ocn843881932
- Dimensions
- unknown
- Extent
- 1 online resource (xiii, 303 p., [8] p. of plates)
- File format
- unknown
- Form of item
- online
- Isbn
- 9781615191659
- Isbn Type
- (electronic bk.)
- Level of compression
- unknown
- Other physical details
- ill. (some col.).
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
- (OCoLC)843881932
Subject
- Cancer -- Research
- Chronic myeloid leukemia -- Genetic aspects
- Chronic myeloid leukemia -- History
- Electronic books
- Fusion Proteins, bcr-abl -- history -- United States
- Genetic Therapy -- history -- United States
- Genetics
- HEALTH & FITNESS / Diseases / Cancer
- History
- Hungerford, David S, 1938-
- Imatinib
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- history -- United States
- MEDICAL / Oncology
- Mutation (Biology)
- Philadelphia Chromosome -- United States
- SCIENCE / Life Sciences / Genetics & Genomics
- Cancer -- Genetic aspects
Genre
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.calgarylibrary.ca/portal/The-Philadelphia-chromosome--a-mutant-gene-and/VlDMiMu7wOk/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.calgarylibrary.ca/portal/The-Philadelphia-chromosome--a-mutant-gene-and/VlDMiMu7wOk/">The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, (electronic resource)</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.calgarylibrary.ca/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.calgarylibrary.ca/">Calgary Public Library</a></span></span></span></span></div>
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.calgarylibrary.ca/portal/The-Philadelphia-chromosome--a-mutant-gene-and/VlDMiMu7wOk/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.calgarylibrary.ca/portal/The-Philadelphia-chromosome--a-mutant-gene-and/VlDMiMu7wOk/">The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, (electronic resource)</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.calgarylibrary.ca/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.calgarylibrary.ca/">Calgary Public Library</a></span></span></span></span></div>