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The Resource The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, (electronic resource)

The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, (electronic resource)

Creator
Contributor
Summary
This work focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this astounding publication
Language
eng
Work
Publication
Extent
1 online resource (xiii, 303 p., [8] p. of plates)
Note
"This book draws extensively from interviews [the author] conducted with those who lived this story. Chronic myeloid leukemia (CML), the blood cancer that is this book's focus, is alternately referred to as chronic myelogenous leukemia."--Author's note
Contents
  • Down to the bone : February 2012
  • The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes"
  • Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man"
  • Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory
  • Aftermath. A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer
  • Survival time
Isbn
9781615191659
Link
http://calgary.lib.overdrive.com/ContentDetails.htm?ID=7F8FC03B-0CC5-4362-BF9C-202EC824D3FE
Instance
Label
The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level
Title
The Philadelphia chromosome
Title remainder
a mutant gene and the quest to cure cancer at the genetic level
Statement of responsibility
Jessica Wapner ; foreword by Robert A. Weinberg
Creator
Contributor
Subject
Genre
Language
eng
Summary
This work focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this astounding publication
Cataloging source
N$T
http://library.link/vocab/creatorName
Wapner, Jessica
Dewey number
616.99/419042
Illustrations
  • illustrations
  • plates
Index
index present
LC call number
RC643
LC item number
.W36 2013eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QZ 11 AA1
http://library.link/vocab/relatedWorkOrContributorDate
1942-
http://library.link/vocab/relatedWorkOrContributorName
Weinberg, Robert A.
http://library.link/vocab/subjectName
  • Hungerford, David S
  • Chronic myeloid leukemia
  • Chronic myeloid leukemia
  • Cancer
  • Cancer
  • Mutation (Biology)
  • Imatinib
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Philadelphia Chromosome
  • Fusion Proteins, bcr-abl
  • Genetic Therapy
  • HEALTH & FITNESS / Diseases / Cancer
  • MEDICAL / Oncology
  • SCIENCE / Life Sciences / Genetics & Genomics
  • History
  • Genetics
Label
The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, (electronic resource)
Link
http://calgary.lib.overdrive.com/ContentDetails.htm?ID=7F8FC03B-0CC5-4362-BF9C-202EC824D3FE
Instantiates
Publication
Note
"This book draws extensively from interviews [the author] conducted with those who lived this story. Chronic myeloid leukemia (CML), the blood cancer that is this book's focus, is alternately referred to as chronic myelogenous leukemia."--Author's note
Antecedent source
unknown
Bibliography note
Includes bibliographical references (p. 283-290) and index
Color
multicolored
Contents
Down to the bone : February 2012 -- The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes" -- Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man" -- Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory -- Aftermath. A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer -- Survival time
Control code
ocn843881932
Dimensions
unknown
Extent
1 online resource (xiii, 303 p., [8] p. of plates)
File format
unknown
Form of item
online
Isbn
9781615191659
Isbn Type
(electronic bk.)
Level of compression
unknown
Other physical details
ill. (some col.).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)843881932
Label
The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, (electronic resource)
Link
http://calgary.lib.overdrive.com/ContentDetails.htm?ID=7F8FC03B-0CC5-4362-BF9C-202EC824D3FE
Publication
Note
"This book draws extensively from interviews [the author] conducted with those who lived this story. Chronic myeloid leukemia (CML), the blood cancer that is this book's focus, is alternately referred to as chronic myelogenous leukemia."--Author's note
Antecedent source
unknown
Bibliography note
Includes bibliographical references (p. 283-290) and index
Color
multicolored
Contents
Down to the bone : February 2012 -- The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes" -- Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man" -- Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory -- Aftermath. A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer -- Survival time
Control code
ocn843881932
Dimensions
unknown
Extent
1 online resource (xiii, 303 p., [8] p. of plates)
File format
unknown
Form of item
online
Isbn
9781615191659
Isbn Type
(electronic bk.)
Level of compression
unknown
Other physical details
ill. (some col.).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)843881932

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